Dr. Mario Online Rx stylized as Dr. Mario Online ? and released in PAL regions as Dr. Mario & Germ Buster is a puzzle video game starring Dr. Mario. It was one of the WiiWare launch games in Japan Europe and Australia and was released in 2008 on March 25 for Japan on May 20 for Europe and Australia and for North America on May 26. As with other Dr. Mario games players must manipulate pills to destroy colored viruses in the game area. Dr. Mario Online Rx features versions of the Nintendo DS title Brain Age 2's mini-games called Virus Buster and Germ Buster which uses the pointer function of the Wii Remote to move pills and allows up to four players to participate cooperatively.