Destroy All Humans! 2 is a 2006 action-adventure video game developed by Pandemic Studios and published by THQ for PlayStation 2 and Xbox. The game is the sequel to Destroy All Humans! and the second installment in the Destroy All Humans! franchise. It also marks the final game in the series to be developed by Pandemic Studios as the company was later acquired by Electronic Arts in 2007. A remake of the game titled Destroy All Humans! 2: Reprobed was initially released in August 2022. This game is set during the year 1969 (10 years after the original game) and begins with a Soviet KGB slide show meeting showing that the main character from Destroy All Humans! Cryptosporidium-137 is suddenly deceased for unknown reasons. His clone Cryptosporidium-138 (Crypto for short) made of more pure Furon DNA is now taking his place and continuing to pose as the President of the United States. KGB intelligence reveals that Crypto-138 is the first and only Furon to have genitalia referred to only as "The Package". Seeing the Furons as a threat to the Soviet Union the KGB destroy the Furon mothership with a nuclear missile.