Duke Nukem takes his Mighty Boot to the Big Apple. Using GLOPP (Gluon Liquid Omega-Phased Plasma) the maniacal mech Morphix has transformed the creatures of New York City into an army of bloodthirsty mutants. In Duke Nukem: Manhattan Project Duke must deploy WIN (Weapons Insults and Name-Calling) to rid the city of goo-based bad guys and return peace and tranquility to The City That Never Sleeps.